Captain Virat Kohli has recovered from a neck injury and will lead India on their tour of Ireland and England.
Kohli had to cancel a contract with English county team Surrey for this month after being injured in mid-May while fielding in the Indian Premier League.
The injury hasn't been specified. He played the next IPL match then had to rest and recover. He faced a fitness test.
"I'm 100 per cent ready to go - neck is fine," the skipper said at a pre-tour media conference on Friday, the day before the team departed.
"I have passed the fitness test and (am) excited to get back on the field."
The injury has alarmed the Indians because Kohli wasn't a factor in his last Test series in England in 2014, when he scored only 134 runs in 10 innings.
He said India were prepared for "some difficult cricket" in England.
Asked about the swing-bowling conditions in England that had troubled India in the past, Kohli said India would be able to counter all threats because they were a very balanced side.
"India's cricket is in a very exciting phase, especially after victories in South Africa," he said.
India open with Twenty20s on Wednesday and Friday in Dublin, then move to England for three T20s, three one-day internationals and five Tests.